ActiveDriverWGS: A Driver Discovery Tool for Cancer Whole Genomes

A method for finding an enrichment of cancer simple somatic mutations (SNVs and Indels) in functional elements across the human genome. 'ActiveDriverWGS' detects coding and noncoding driver elements using whole genome sequencing data. The method is part of the following publication: Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks. Molecular Cell (2020) <doi:10.1016/j.molcel.2019.12.027>.

Version: 1.2.0
Depends: R (≥ 3.5)
Imports: BSgenome, BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm9, BSgenome.Mmusculus.UCSC.mm10, Biostrings, GenomeInfoDb, GenomicRanges, IRanges, S4Vectors
Suggests: knitr, testthat, rmarkdown
Published: 2022-09-03
Author: Juri Reimand [aut, cre], Helen Zhu [aut], Kevin Cheng [ctb]
Maintainer: Juri Reimand <juri.reimand at>
License: GPL-3
NeedsCompilation: no
Materials: README NEWS
CRAN checks: ActiveDriverWGS results


Reference manual: ActiveDriverWGS.pdf
Vignettes: ActiveDriverWGS


Package source: ActiveDriverWGS_1.2.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available
Old sources: ActiveDriverWGS archive


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