This vignette gives a few examples of the use of the
**emmeans** package to analyze other than the basic types
of models provided by the **stats** package. Emphasis here
is placed on accessing the optional capabilities that are typically not
needed for the more basic models. A reference for all supported models
is provided in the “models” vignette.

Linear mixed models are really important in statistics. Emphasis here
is placed on those fitted using `lme4::lmer()`

, but
**emmeans** also supports other mixed-model packages such
as **nlme**.

To illustrate, consider the `Oats`

dataset in the
**nlme** package. It has the results of a balanced
split-plot experiment: experimental blocks are divided into plots that
are randomly assigned to oat varieties, and the plots are subdivided
into subplots that are randomly assigned to amounts of nitrogen within
each plot. We will consider a linear mixed model for these data,
excluding interaction (which is justified in this case). For sake of
illustration, we will exclude a few observations.

```
Oats.lmer <- lme4::lmer(yield ~ Variety + factor(nitro) + (1|Block/Variety),
data = nlme::Oats, subset = -c(1,2,3,5,8,13,21,34,55))
```

Let’s look at the EMMs for `nitro`

:

```
Oats.emm.n <- emmeans(Oats.lmer, "nitro")
Oats.emm.n
```

```
## nitro emmean SE df lower.CL upper.CL
## 0.0 78.9 7.29 7.78 62.0 95.8
## 0.2 97.0 7.14 7.19 80.3 113.8
## 0.4 114.2 7.14 7.19 97.4 131.0
## 0.6 124.1 7.07 6.95 107.3 140.8
##
## Results are averaged over the levels of: Variety
## Degrees-of-freedom method: kenward-roger
## Confidence level used: 0.95
```

You will notice that the degrees of freedom are fractional: that is
due to the fact that whole-plot and subplot variations are combined when
standard errors are estimated. Different degrees-of-freedom methods are
available. By default, the Kenward-Roger method is used, and that’s why
you see a message about the **pbkrtest** package being
loaded, as it implements that method. We may specify a different
degrees-of-freedom method via the optional argument
`lmer.df`

:

`emmeans(Oats.lmer, "nitro", lmer.df = "satterthwaite")`

```
## nitro emmean SE df lower.CL upper.CL
## 0.0 78.9 7.28 7.28 61.8 96
## 0.2 97.0 7.13 6.72 80.0 114
## 0.4 114.2 7.13 6.72 97.2 131
## 0.6 124.1 7.07 6.49 107.1 141
##
## Results are averaged over the levels of: Variety
## Degrees-of-freedom method: satterthwaite
## Confidence level used: 0.95
```

This latest result uses the Satterthwaite method, which is
implemented in the **lmerTest** package. Note that, with
this method, not only are the degrees of freedom slightly different, but
so are the standard errors. That is because the Kenward-Roger method
also entails making a bias adjustment to the covariance matrix of the
fixed effects; that is the principal difference between the methods. A
third possibility is `"asymptotic"`

:

`emmeans(Oats.lmer, "nitro", lmer.df = "asymptotic")`

```
## nitro emmean SE df asymp.LCL asymp.UCL
## 0.0 78.9 7.28 Inf 64.6 93.2
## 0.2 97.0 7.13 Inf 83.1 111.0
## 0.4 114.2 7.13 Inf 100.2 128.2
## 0.6 124.1 7.07 Inf 110.2 137.9
##
## Results are averaged over the levels of: Variety
## Degrees-of-freedom method: asymptotic
## Confidence level used: 0.95
```

This just sets all the degrees of freedom to `Inf`

–
that’s **emmeans**’s way of using *z* statistics
rather than *t* statistics. The asymptotic methods tend to make
confidence intervals a bit too narrow and P values a bit too low; but
they involve much, much less computation. Note that the SEs are the same
as obtained using the Satterthwaite method.

Comparisons and contrasts are pretty much the same as with other
models. As `nitro`

has quantitative levels, we might want to
test polynomial contrasts:

`contrast(Oats.emm.n, "poly")`

```
## contrast estimate SE df t.ratio p.value
## linear 152.69 15.58 43.2 9.802 <.0001
## quadratic -8.27 6.95 44.2 -1.190 0.2402
## cubic -6.32 15.21 42.8 -0.415 0.6800
##
## Results are averaged over the levels of: Variety
## Degrees-of-freedom method: kenward-roger
```

The interesting thing here is that the degrees of freedom are much
larger than they are for the EMMs. The reason is because
`nitro`

within-plot factor, so inter-plot variations have
little role in estimating contrasts among `nitro`

levels. On
the other hand, `Variety`

is a whole-plot factor, and there
is not much of a bump in degrees of freedom for comparisons:

`emmeans(Oats.lmer, pairwise ~ Variety)`

```
## $emmeans
## Variety emmean SE df lower.CL upper.CL
## Golden Rain 105.2 7.53 8.46 88.0 122
## Marvellous 108.5 7.48 8.28 91.3 126
## Victory 96.9 7.64 8.81 79.6 114
##
## Results are averaged over the levels of: nitro
## Degrees-of-freedom method: kenward-roger
## Confidence level used: 0.95
##
## $contrasts
## contrast estimate SE df t.ratio p.value
## Golden Rain - Marvellous -3.23 6.55 9.56 -0.493 0.8764
## Golden Rain - Victory 8.31 6.71 9.80 1.238 0.4595
## Marvellous - Victory 11.54 6.67 9.80 1.729 0.2431
##
## Results are averaged over the levels of: nitro
## Degrees-of-freedom method: kenward-roger
## P value adjustment: tukey method for comparing a family of 3 estimates
```

The computation required to compute the adjusted covariance matrix
and degrees of freedom may become cumbersome. Some user options (i.e.,
`emm_options()`

calls) make it possible to streamline these
computations through default methods and limitations on them. First, the
option `lmer.df`

, which may have values of
`"kenward-roger"`

, `"satterthwaite"`

, or
`"asymptotic"`

(partial matches are OK!) specifies the
default degrees-of-freedom method.

The options `disable.pbkrtest`

and
`disable.lmerTest`

may be `TRUE`

or
`FALSE`

, and comprise another way of controlling which method
is used (e.g., the Kenward-Roger method will not be used if
`get_emm_option("disable.pbkrtest") == TRUE`

). Finally, the
options `pbkrtest.limit`

and `lmerTest.limit`

,
which should be set to numeric values, enable the given package
conditionally on whether the number of data rows does not exceed the
given limit. The factory default is 3000 for both limits.

If a model is fitted and its formula includes an
`offset()`

term, then by default, the offset is computed and
included in the reference grid. To illustrate, consider a hypothetical
dataset on insurance claims (used as an example
in SAS’s documentation). There are classes of cars of varying counts
(`n`

), sizes (`size`

), and age (`age`

),
and we record the number of insurance claims (`claims`

). We
fit a Poisson model to `claims`

as a function of
`size`

and `age`

. An offset of `log(n)`

is included so that `n`

functions as an “exposure”
variable.

```
ins <- data.frame(
n = c(500, 1200, 100, 400, 500, 300),
size = factor(rep(1:3,2), labels = c("S","M","L")),
age = factor(rep(1:2, each = 3)),
claims = c(42, 37, 1, 101, 73, 14))
ins.glm <- glm(claims ~ size + age + offset(log(n)),
data = ins, family = "poisson")
```

First, let’s look at the reference grid obtained by default:

`ref_grid(ins.glm)`

```
## 'emmGrid' object with variables:
## size = S, M, L
## age = 1, 2
## n = 500
## Transformation: "log"
```

Note that `n`

is included in the reference grid and that
its average value of 500 is used for all predictions. Thus, if we obtain
EMMs for, say, `age`

, these are results are based on a pool
of 500 cars:

`emmeans(ins.glm, "size", type = "response")`

```
## size rate SE df asymp.LCL asymp.UCL
## S 69.3 6.25 Inf 58.03 82.7
## M 34.6 3.34 Inf 28.67 41.9
## L 11.9 3.14 Inf 7.07 19.9
##
## Results are averaged over the levels of: age
## Confidence level used: 0.95
## Intervals are back-transformed from the log scale
```

However, many users would like to ignore the offset for this kind of
model, because then the estimates we obtain are rates per unit value of
the (logged) offset. This may be accomplished by specifying an
`offset`

parameter in the call:

`emmeans(ins.glm, "size", type = "response", offset = 0)`

```
## size rate SE df asymp.LCL asymp.UCL
## S 0.1385 0.01250 Inf 0.1161 0.1653
## M 0.0693 0.00669 Inf 0.0573 0.0837
## L 0.0237 0.00627 Inf 0.0141 0.0398
##
## Results are averaged over the levels of: age
## Confidence level used: 0.95
## Intervals are back-transformed from the log scale
```

You may verify that the above estimates are 1/500th of the previous
ones. You may also verify that the above results are identical to those
obtained by setting `n`

equal to 1:

`emmeans(ins.glm, "size", type = "response", at = list(n = 1))`

However, those who use these types of models will be more comfortable directly setting the offset to zero.

By the way, you may set some other reference value for the rates. For example, if you want estimates of claims per 100 cars, simply use (results not shown):

`emmeans(ins.glm, "size", type = "response", offset = log(100))`

Ordinal-response models comprise an example where several options are
available for obtaining EMMs. To illustrate, consider the
`wine`

data in the **ordinal** package. The
response is a rating of bitterness on a five-point scale. we will
consider a probit model in two factors during fermentation:
`temp`

(temperature) and `contact`

(contact with
grape skins), with the judge making the rating as a scale predictor:

`require("ordinal")`

`## Loading required package: ordinal`

```
##
## Attaching package: 'ordinal'
```

```
## The following objects are masked from 'package:lme4':
##
## VarCorr, ranef
```

```
wine.clm <- clm(rating ~ temp + contact, scale = ~ judge,
data = wine, link = "probit")
```

(in earlier modeling, we found little interaction between the factors.) Here are the EMMs for each factor using default options:

`emmeans(wine.clm, list(pairwise ~ temp, pairwise ~ contact))`

```
## $`emmeans of temp`
## temp emmean SE df asymp.LCL asymp.UCL
## cold -0.884 0.290 Inf -1.452 -0.316
## warm 0.601 0.225 Inf 0.161 1.041
##
## Results are averaged over the levels of: contact, judge
## Confidence level used: 0.95
##
## $`pairwise differences of temp`
## 1 estimate SE df z.ratio p.value
## cold - warm -1.07 0.422 Inf -2.547 0.0109
##
## Results are averaged over the levels of: contact, judge
##
## $`emmeans of contact`
## contact emmean SE df asymp.LCL asymp.UCL
## no -0.614 0.298 Inf -1.1990 -0.0297
## yes 0.332 0.201 Inf -0.0632 0.7264
##
## Results are averaged over the levels of: temp, judge
## Confidence level used: 0.95
##
## $`pairwise differences of contact`
## 1 estimate SE df z.ratio p.value
## no - yes -0.684 0.304 Inf -2.251 0.0244
##
## Results are averaged over the levels of: temp, judge
```

These results are on the “latent” scale; the idea is that there is a continuous random variable (in this case normal, due to the probit link) having a mean that depends on the predictors; and that the ratings are a discretization of the latent variable based on a fixed set of cut points (which are estimated). In this particular example, we also have a scale model that says that the variance of the latent variable depends on the judges. The latent results are quite a bit like those for measurement data, making them easy to interpret. The only catch is that they are not uniquely defined: we could apply a linear transformation to them, and the same linear transformation to the cut points, and the results would be the same.

The `clm`

function actually fits the model using an
ordinary probit model but with different intercepts for each cut point.
We can get detailed information for this model by specifying
`mode = "linear.predictor"`

:

```
tmp <- ref_grid(wine.clm, mode = "lin")
tmp
```

```
## 'emmGrid' object with variables:
## temp = cold, warm
## contact = no, yes
## judge = 1, 2, 3, 4, 5, 6, 7, 8, 9
## cut = multivariate response levels: 1|2, 2|3, 3|4, 4|5
## Transformation: "probit"
```

Note that this reference grid involves an additional constructed
predictor named `cut`

that accounts for the different
intercepts in the model. Let’s obtain EMMs for `temp`

on the
linear-predictor scale:

`emmeans(tmp, "temp")`

```
## temp emmean SE df asymp.LCL asymp.UCL
## cold 0.884 0.290 Inf 0.316 1.452
## warm -0.601 0.225 Inf -1.041 -0.161
##
## Results are averaged over the levels of: contact, judge, cut
## Results are given on the probit (not the response) scale.
## Confidence level used: 0.95
```

These are just the negatives of the latent results obtained earlier
(the sign is changed to make the comparisons go the right direction).
Closely related to this is `mode = "cum.prob"`

and
`mode = "exc.prob"`

, which simply transform the linear
predictor to cumulative probabilities and exceedance (1 - cumulative)
probabilities. These modes give us access to the details of the fitted
model but are cumbersome to use for describing results. When they can
become useful is when you want to work in terms of a particular cut
point. Let’s look at `temp`

again in terms of the probability
that the rating will be at least 4:

`emmeans(wine.clm, ~ temp, mode = "exc.prob", at = list(cut = "3|4"))`

```
## temp exc.prob SE df asymp.LCL asymp.UCL
## cold 0.0748 0.0318 Inf 0.0124 0.137
## warm 0.4069 0.0706 Inf 0.2686 0.545
##
## Results are averaged over the levels of: contact, judge
## Confidence level used: 0.95
```

There are yet more modes! With `mode = "prob"`

, we obtain
estimates of the probability distribution of each rating. Its reference
grid includes a factor with the same name as the model response – in
this case `rating`

. We usually want to use that as the
primary factor, and the factors of interest as `by`

variables:

`emmeans(wine.clm, ~ rating | temp, mode = "prob")`

```
## temp = cold:
## rating prob SE df asymp.LCL asymp.UCL
## 1 0.1292 0.0625 Inf 0.00667 0.2518
## 2 0.4877 0.0705 Inf 0.34948 0.6259
## 3 0.3083 0.0594 Inf 0.19186 0.4248
## 4 0.0577 0.0238 Inf 0.01104 0.1043
## 5 0.0171 0.0127 Inf -0.00768 0.0419
##
## temp = warm:
## rating prob SE df asymp.LCL asymp.UCL
## 1 0.0156 0.0129 Inf -0.00961 0.0408
## 2 0.1473 0.0448 Inf 0.05959 0.2350
## 3 0.4302 0.0627 Inf 0.30723 0.5532
## 4 0.2685 0.0625 Inf 0.14593 0.3910
## 5 0.1384 0.0506 Inf 0.03923 0.2376
##
## Results are averaged over the levels of: contact, judge
## Confidence level used: 0.95
```

Using `mode = "mean.class"`

obtains the average of these
probability distributions as probabilities of the integers 1–5:

`emmeans(wine.clm, "temp", mode = "mean.class")`

```
## temp mean.class SE df asymp.LCL asymp.UCL
## cold 2.35 0.144 Inf 2.06 2.63
## warm 3.37 0.146 Inf 3.08 3.65
##
## Results are averaged over the levels of: contact, judge
## Confidence level used: 0.95
```

And there is a mode for the scale model too. In this example, the scale model involves only judges, and that is the only factor in the grid:

`summary(ref_grid(wine.clm, mode = "scale"), type = "response")`

```
## judge response SE df
## 1 1.000 0.000 Inf
## 2 1.043 0.570 Inf
## 3 1.053 0.481 Inf
## 4 0.710 0.336 Inf
## 5 0.663 0.301 Inf
## 6 0.758 0.341 Inf
## 7 1.071 0.586 Inf
## 8 0.241 0.179 Inf
## 9 0.533 0.311 Inf
```

Judge 8’s ratings don’t vary much, relative to the others. The scale model is in terms of log(SD). Again, these are not uniquely identifiable, and the first level’s estimate is set to log(1) = 0. so, actually, each estimate shown is a comparison with judge 1.

To illustrate **emmeans**’s support for models fitted
using MCMC methods, consider the `example_model`

available in
the **rstanarm** package. The example concerns CBPP, a
serious disease of cattle in Ethiopia. A generalized linear mixed model
was fitted to the data using the code below. (This is a Bayesian
equivalent of the frequentist model we considered in the “Transformations” vignette.) In
fitting the model, we first set the contrast coding to
`bayestestR::contr.bayes`

because this equalizes the priors
across different treatment levels (a correction from an earlier version
of this vignette.) We subsequently obtain the reference grids for these
models in the usual way. For later use, we also fit the same model with
just the prior information.

```
cbpp <- transform(lme4::cbpp, unit = 1:56)
require("bayestestR")
options(contrasts = c("contr.bayes", "contr.poly"))
cbpp.rstan <- rstanarm::stan_glmer(
cbind(incidence, size - incidence) ~ period + (1|herd) + (1|unit),
data = cbpp, family = binomial,
prior = student_t(df = 5, location = 0, scale = 2, autoscale = FALSE),
chains = 2, cores = 1, seed = 2021.0120, iter = 1000)
cbpp_prior.rstan <- update(cbpp.rstan, prior_PD = TRUE)
cbpp.rg <- ref_grid(cbpp.rstan)
cbpp_prior.rg <- ref_grid(cbpp_prior.rstan)
```

Here is the structure of the reference grid:

`cbpp.rg`

```
## 'emmGrid' object with variables:
## period = 1, 2, 3, 4
## Transformation: "logit"
```

So here are the EMMs (no averaging needed in this simple model):

`summary(cbpp.rg)`

```
## period prediction lower.HPD upper.HPD
## 1 -1.60 -2.26 -0.987
## 2 -2.77 -3.65 -1.974
## 3 -2.90 -3.77 -2.040
## 4 -3.32 -4.43 -2.385
##
## Point estimate displayed: median
## Results are given on the logit (not the response) scale.
## HPD interval probability: 0.95
```

The summary for EMMs of Bayesian models shows the median of the
posterior distribution of each estimate, along with highest posterior
density (HPD) intervals. Under the hood, the posterior sample of
parameter estimates is used to compute a corresponding sample of
posterior EMMs, and it is those that are summarized. (Technical note:
the summary is actually rerouted to the `hpd.summary()`

function.

We can access the posterior EMMs via the `as.mcmc`

method
for `emmGrid`

objects. This gives us an object of class
`mcmc`

(defined in the **coda** package), which
can be summarized and explored as we please.

`require("coda")`

`## Loading required package: coda`

`summary(as.mcmc(cbpp.rg))`

```
##
## Iterations = 1:500
## Thinning interval = 1
## Number of chains = 2
## Sample size per chain = 500
##
## 1. Empirical mean and standard deviation for each variable,
## plus standard error of the mean:
##
## Mean SD Naive SE Time-series SE
## period 1 -1.595 0.3333 0.01054 0.01279
## period 2 -2.790 0.4327 0.01368 0.01367
## period 3 -2.916 0.4491 0.01420 0.01706
## period 4 -3.379 0.5384 0.01703 0.01845
##
## 2. Quantiles for each variable:
##
## 2.5% 25% 50% 75% 97.5%
## period 1 -2.283 -1.823 -1.597 -1.357 -0.9929
## period 2 -3.707 -3.038 -2.766 -2.511 -2.0197
## period 3 -3.834 -3.196 -2.899 -2.610 -2.0915
## period 4 -4.502 -3.725 -3.318 -3.022 -2.4079
```

Note that `as.mcmc`

will actually produce an
`mcmc.list`

when there is more than one chain present, as in
this example. The 2.5th and 97.5th quantiles are similar, but not
identical, to the 95% confidence intervals in the frequentist
summary.

The **bayestestR** package provides `emmGrid`

methods for most of its description and testing functions. For
example:

`bayestestR::bayesfactor_parameters(pairs(cbpp.rg), prior = pairs(cbpp_prior.rg))`

```
## Warning: Bayes factors might not be precise.
## For precise Bayes factors, sampling at least 40,000 posterior samples is recommended.
```

```
## Bayes Factor (Savage-Dickey density ratio)
##
## Parameter | BF
## -------------------------
## period1 - period2 | 3.01
## period1 - period3 | 5.13
## period1 - period4 | 14.26
## period2 - period3 | 0.173
## period2 - period4 | 0.268
## period3 - period4 | 0.221
##
## * Evidence Against The Null: 0
```

`bayestestR::p_rope(pairs(cbpp.rg), range = c(-0.25, 0.25))`

```
## Proportion of samples inside the ROPE [-0.25, 0.25]
##
## Parameter | p (ROPE)
## ----------------------------
## period1 - period2 | 0.021
## period1 - period3 | 0.015
## period1 - period4 | 0.004
## period2 - period3 | 0.367
## period2 - period4 | 0.184
## period3 - period4 | 0.290
```

Both of these sets of results suggest that period 1 is different from
the others. For more information on these methods, refer to the CRAN page for
**bayestestR** and its vignettes, e.g., the one on
Bayes factors.

Next, let us consider the back-transformed results. As is discussed
with the frequentist model,
there are random effects present, and if wee want to think in terms of
marginal probabilities across all herds and units, we should correct for
bias; and to do that, we need the standard deviations of the random
effects. The model object has MCMC results for the random effects of
each herd and each unit, but after those, there are also summary results
for the posterior SDs of the two random effects. (I used the
`colnames`

function to find that they are in the 78th and
79th columns.)

`cbpp.sigma = as.matrix(cbpp.rstan$stanfit)[, 78:79]`

Here are the first few:

`head(cbpp.sigma)`

```
## parameters
## iterations Sigma[unit:(Intercept),(Intercept)] Sigma[herd:(Intercept),(Intercept)]
## [1,] 1.154694 0.167807505
## [2,] 1.459379 0.040318460
## [3,] 1.482619 0.006198847
## [4,] 1.236694 0.206057981
## [5,] 1.460472 0.088491844
## [6,] 1.412277 0.070334431
```

So to obtain bias-adjusted marginal probabilities, obtain the resultant SD and regrid with bias correction:

```
totSD <- sqrt(apply(cbpp.sigma^2, 1, sum))
cbpp.rgrd <- regrid(cbpp.rg, bias.adjust = TRUE, sigma = totSD)
summary(cbpp.rgrd)
```

```
## period prob lower.HPD upper.HPD
## 1 0.2192 0.1207 0.377
## 2 0.0856 0.0285 0.176
## 3 0.0747 0.0288 0.163
## 4 0.0506 0.0136 0.120
##
## Point estimate displayed: median
## HPD interval probability: 0.95
```

Here is a plot of the posterior incidence probabilities, back-transformed:

`bayesplot::mcmc_areas(as.mcmc(cbpp.rgrd))`

… and here are intervals for each period compared with its neighbor:

`contrast(cbpp.rgrd, "consec", reverse = TRUE)`

```
## contrast estimate lower.HPD upper.HPD
## period1 - period2 0.13379 0.0258 0.274
## period2 - period3 0.00864 -0.0714 0.111
## period3 - period4 0.02317 -0.0564 0.114
##
## Point estimate displayed: median
## HPD interval probability: 0.95
```

The only interval that excludes zero is the one that compares periods 1 and 2.

To predict from an MCMC model, just specify the
`likelihood`

argument in `as.mcmc`

. Doing so
causes the function to simulate data from the posterior predictive
distribution. For example, if we want to predict the CBPP incidence in
future herds of 25 cattle, we can do:

```
set.seed(2019.0605)
cbpp.preds <- as.mcmc(cbpp.rgrd, likelihood = "binomial", trials = 25)
bayesplot::mcmc_hist(cbpp.preds, binwidth = 1)
```